• Katie Floyd

The Effects of Chlorophyllin on Liver Fibrosis

Updated: Feb 26, 2020

A recent animal study linked chlorophyllin to improved liver health, specifically liver fibrosis. Liver Fibrosis occurs when healthy liver tissue becomes scarred. If enough of the liver becomes scarred, it develops into liver cirrhosis.

According to Heathline, fibrosis is the first stage of liver scarring and occurs when the liver attempts to repair and replace damaged cells after a person experiences liver injury or inflammation. The liver’s cells then stimulate wound healing. This process causes excess proteins to build up in the liver. Eventually, after the liver attempts to repair itself numerous times, the liver cells cannot repair themselves anymore, and the excess proteins form scar tissue or fibrosis. There are several types of liver diseases that can cause fibrosis, such as autoimmune hepatitis, viral hepatitis B and C, biliary obstruction, and alcoholic liver disease. (1)

The study objective was to examine chlorophyllin, derived from chlorophyll, and its effects on liver fibrosis. The effects were evaluated for (1.) survival rate, (2.) hepatic morphologic analysis, (3.) inflammatory factors in both the small intestine and liver, and (4.) gut microbiota.

Results from the study indicate that oral chlorophyllin treatment could reduce intestine and liver inflammation and improve liver fibrosis. Chlorophyllin treatment also significantly reduced necro-inflammation and liver injury. Additionally, chlorophyllin treatment reduced mortality of the mice in the study from 50% to 25%. Further results indicated that chlorophyllin can also directly impact gut microbiota. In particular, the administration of chlorophyllin can quickly rebalance the gut microbiota. (2)

Read the full study here: https://www.frontiersin.org/articles/10.3389/fphys.2018.01671/full#F1

(1) “Liver Fibrosis.” Healthline, https://www.healthline.com/health/liver-fibrosis. Accessed 13 February 2020.

(2) Zheng, Han, et al. “Chlorophyllin Modulates Gut Microbiota and Inhibits Intestinal Inflammation to Ameliorate Hepatic Fibrosis in Mice.” Frontiers in Physiology, vol. 9, Dec. 2018, p. 1671, doi:10.3389/fphys.2018.01671.

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